I am very thankful that neither my stage-4 breast cancer wife and my cardio-vascular compromised self have thus far avoided this plague.
Similarly, I am very thankful that unborn/infant mortality hasn't been a facet of this. We'd have had a totally different response. (Instead, it was just killing the old and sick, so who cares?...)
I am very thankful that neither my stage-4 breast cancer wife and my cardio-vascular compromised self have thus far avoided this plague.
Similarly, I am very thankful that unborn/infant mortality hasn't been a facet of this. We'd have had a totally different response. (Instead, it was just killing the old and sick, so who cares?...)
Post-COVID Fatigue, Exercise Intolerance
Signal ME/CFS
This is behind a paywall, so I copied a lot of the text. Boldface done by me:
A new study provides yet more evidence that a significant subset of people who experience persistent fatigue and exercise intolerance following COVID-19 will meet diagnostic criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
Data from the prospective observational study of 42 patients with "post-COVID-19 syndrome (PCS)," including persistent fatigue and exercise intolerance, suggest that a large proportion will meet strict diagnostic criteria for ME/CFS, including the hallmark post-exertional malaise (PEM). Still others may experience similar disability but lack duration and/or severity requirements for the diagnosis.
Moreover, disease severity and symptom burden were found similar in those with ME/CFS following COVID-19 and in a group of 19 age- and sex-matched individuals with ME/CFS that wasn't associated with COVID-19.
Of the 42 with PCS, including persistent fatigue and exercise intolerance lasting at least 6 months, 19 met the rigorous Canadian Consensus Criteria (CCC) for ME/CFS, established in 2003, which require PEM, along with sleep dysfunction, significant persistent fatigue, pain, and several other symptoms from neurological/cognitive, autonomic, neuroendocrine, and immune categories that persist for at least 6 months.
Of the 23 who did not meet the CCC criteria, 18 still experienced PEM but for less than the required 14 hours set by the authors based on recent data. The original CCC had suggested 24 hours as the PEM duration. Eight subjects met all the Canadian criteria except for the neurological/cognitive symptoms. None of the 42 had evidence of severe depression.
The previously widely used 1994 "Fukuda" criteria for ME/CFS are no longer recommended because they don't require PEM, which is now considered a key symptom. The more recent 2015 Institute (now Academy) of Medicine criteriadon't define the length of PEM, the authors note in the paper.
Scheibenbogen said, "Post-COVID has a spectrum of syndromes and conditions. We see that a subset of patients have similar symptoms of ME/CFS but don't fulfill the CCC, although they may meet less stringent criteria. We think this is of relevance for both diagnostic markers and development of therapy, because there may be different pathomechanisms between the subsets of post-COVID patients."
She pointed to other studies from her group suggesting that inflammation is present early in post-COVID (not yet published), while in the subset that goes on to ME/CFS, autoantibodies or endothelial dysfunction play a more important role. "At the moment, it's quite complex, and I don't think in the end we will have just one pathomechanism. So I think we'll need to develop various treatment strategies."
I am very thankful that neither my stage-4 breast cancer wife and my cardio-vascular compromised self have thus far avoided this plague.
Post-COVID Fatigue, Exercise Intolerance
Signal ME/CFS
This is behind a paywall, so I copied a lot of the text. Boldface done by me:
A new study provides yet more evidence that a significant subset of people who experience persistent fatigue and exercise intolerance following COVID-19 will meet diagnostic criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
Data from the prospective observational study of 42 patients with "post-COVID-19 syndrome (PCS)," including persistent fatigue and exercise intolerance, suggest that a large proportion will meet strict diagnostic criteria for ME/CFS, including the hallmark post-exertional malaise (PEM). Still others may experience similar disability but lack duration and/or severity requirements for the diagnosis.
Moreover, disease severity and symptom burden were found similar in those with ME/CFS following COVID-19 and in a group of 19 age- and sex-matched individuals with ME/CFS that wasn't associated with COVID-19.
Of the 42 with PCS, including persistent fatigue and exercise intolerance lasting at least 6 months, 19 met the rigorous Canadian Consensus Criteria (CCC) for ME/CFS, established in 2003, which require PEM, along with sleep dysfunction, significant persistent fatigue, pain, and several other symptoms from neurological/cognitive, autonomic, neuroendocrine, and immune categories that persist for at least 6 months.
Of the 23 who did not meet the CCC criteria, 18 still experienced PEM but for less than the required 14 hours set by the authors based on recent data. The original CCC had suggested 24 hours as the PEM duration. Eight subjects met all the Canadian criteria except for the neurological/cognitive symptoms. None of the 42 had evidence of severe depression.
The previously widely used 1994 "Fukuda" criteria for ME/CFS are no longer recommended because they don't require PEM, which is now considered a key symptom. The more recent 2015 Institute (now Academy) of Medicine criteriadon't define the length of PEM, the authors note in the paper.
Scheibenbogen said, "Post-COVID has a spectrum of syndromes and conditions. We see that a subset of patients have similar symptoms of ME/CFS but don't fulfill the CCC, although they may meet less stringent criteria. We think this is of relevance for both diagnostic markers and development of therapy, because there may be different pathomechanisms between the subsets of post-COVID patients."
She pointed to other studies from her group suggesting that inflammation is present early in post-COVID (not yet published), while in the subset that goes on to ME/CFS, autoantibodies or endothelial dysfunction play a more important role. "At the moment, it's quite complex, and I don't think in the end we will have just one pathomechanism. So I think we'll need to develop various treatment strategies."
I wonder how unique long covid is relative to other microbrial infections - e.g, epstein barr, lyme and other chronic conditions that persist after acute infections.
It certainly been tracked better, with more reliable data.
p.s., western medicine is not particularly effective "curing" these lingering morbidities (although they can treat symptoms). Here lifestyle changes, exercise, diet, herbs... are critical.
Exercise, physical activity are critical. There are legions of unhealthy folks out there who believe they can simply eat their way to better health.
I wonder how unique long covid is relative to other microbrial infections - e.g, epstein barr, lyme and other chronic conditions that persist after acute infections.
It certainly been tracked better, with more reliable data.
p.s., western medicine is not particularly effective "curing" these lingering morbidities (although they can treat symptoms). Here lifestyle changes, exercise, diet, herbs... are critical.
in the US we're at a point where quite a few people don't report infections
obviously that would make it more difficult to track
is the cdc open about their data? i believe moreso than china
however there has been some incompetence and no doubt they were ill prepared to respond and report accurately as we would like
your links above might help illustrate that
i think the key issue i'm making here is intention
the ccp has really tight control of their reporting/data
and their numbers are nothing short unbelievable/unrealistic
hong kong (versus shenzhen and the rest of china) is another eye-popping example COVID-19 misinformation by China
Judging by the numbers, China appears to be experiencing a far different pandemic than the rest of the world. In the latest surge in Shanghai, its largest city with a population of 25 million, China has reported more than 300,000 cases since early March and no deaths. By contrast, the world as a whole has experienced about 195 deaths for every 100,000 population as of last November. Can Chinaâs statistics be believed?
Judging by the numbers, China appears to be experiencing a far different pandemic than the rest of the world. In the latest surge in Shanghai, its largest city with a population of 25 million, China has reported more than 300,000 cases since early March and no deaths. By contrast, the world as a whole has experienced about 195 deaths for every 100,000 population as of last November. Can Chinaâs statistics be believed?
You don't want shingles. Seriously. Get the vaccine, y'all.
Glad to hear you and yours are doing better, Kurt.
yeah i got the original shingles vax years ago
and about three years ago i was double jabbed with shingrix
only seen shingles up close three or four times
it was awful and that was enough...
